Review of 21 studies suggests 25 percent of children and adolescents develop lung COVID after being infected

A significant number of children and adolescents appear to experience symptoms of COVID-19 months after being diagnosed with the disease.

Researchers from Rutgers, Harvard and Emory University, as well as Mexico, Sweden and the Houston Methodist Research Institute came to this conclusion after reviewing 21 studies of Lung COVID in PubMed and Embase.

“A total of 80,071 children and adolescents with COVID-19 were included,” they said in their research paper.

The researchers determined that the prevalence of Lung COVID was 25.24 percent. Mood disturbances, fatigue and sleep disturbances were the most common clinical manifestations, according to the study.

The lead author, Sandra Lopez-Leon, is an employee of Novartis Pharmaceutical Company, although the paper states that statements “do not necessarily represent the position of the company.” None of the other seven authors disclosed any conflict of interest.

The paper is a preprint that has not yet undergone peer review, so it should not be used as a guideline for clinical practice.

The studies selected for research had to meet five criteria:

* minimum of 30 patients;

* ages ranging from 0 to 18 years:

* published in English;

* published before February 10, 2022;

*meets the National Institute for Healthcare Excellence (NICE) definition of long-term COVID, which consists of both persistent (4 to 12 weeks) and post-COVID-19 (≥12 weeks) symptoms.

dr. Bonnie Henry sees no need for a mask mandate in public schools, even though less than half of all children ages five to 11 have had two doses of a COVID-19 vaccine.

No mandate for indoor masks in the entire province

Despite growing awareness of Lung COVID, BC Provincial Health Officer Dr. Bonnie Henry, a countywide mandatory mask mandate was lifted on March 11 under almost all circumstances. She kept it in public schools until the end of spring break.

As of May 29, only 57 percent of BC children between the ages of five and 11 had received one dose of a COVID-19 vaccine. By that date, 44 percent between the ages of five and 11 had received two doses of a COVID-19 vaccine, according to the BC Center for Disease Control.

Of those ages 12 to 17, 89 percent had received one dose and 86 percent had received two doses by May 29. Thirty-six percent of 12- to 17-year-olds have received a third dose of a COVID-19. vaccine.

The University of British Columbia chose to keep its mandate for indoor masks, but to date no school district in BC has followed suit, even though they have this authority as employers.

The World Health Organization defines “post-COVID-19 condition” as “the illness that occurs in people with a history of probable or confirmed SARS-CoV-2 infection; usually within three months of the onset of COVID-19, with symptoms and effects that last for at least two months. The symptoms and effects of a post-COVID-19 condition cannot be explained by an alternative diagnosis.”

According to the WHO, most people make a full recovery from COVID-19, but “current evidence suggests that about 10%-20% of people experience a variety of medium- and long-term effects after recovering from their first illness”.

One of the most complex medical conditions

In 2021 a paper appeared in the International Journal of Immunopathology and Pharmacology described COVID-19 as a “highly heterogeneous and complex medical condition”.

The fourth authors of “A scoping review of the pathophysiology of COVID-19” claimed that “severe COVID-19 is probably one of the most complex medical conditions known to medical science.”

“While tremendous progress has been made in understanding the molecular pathways involved in patients infected with coronaviruses, an overarching and comprehensive understanding of the pathogenesis of COVID-19 is lacking,” they stated. “Such understanding is essential in formulating effective prophylactic and treatment strategies.”

They pointed to three fundamental pathological processes, based on clinical, proteomic and genomic studies and autopsy data. They include:

* pulmonary macrophage [a type of white blood cell] activation syndrome with uncontrolled inflammation;

* a complement-mediated endothelialitis [swollen endothelial cells, which are found in most arteries, veins, and capillaries of the brain, skin, lung, heart, and muscle] along with a procoagulant state with a thrombotic microangiopathy [syndromes characerized by the destruction of red blood cells, low platelets, and organ damage due to microscopic blood clots]†

* and platelet activation with the release of serotonin and the activation and degranulation of mast cells [found in connective tissue, which release substances during inflammatory or allergic reactions]which contributes to the hyperinflammatory state.

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